Samuel Amadi

I am a PharmD trained medical writer with 6+ years of experience supporting and delivering regulatory and medical communications content across pharmaceutical companies, CROs, academic research programs, and agencies.

Selected Work

Informed Consent Form for Phase 2 CAR T Cell Therapy Study in Refractory Idiopathic Inflammatory Myopathies

This informed consent document presents a Phase 2 clinical study evaluating the safety and efficacy of rapcabtagene autoleucel, a CAR T cell therapy, compared with standard treatments in patients with severe refractory idiopathic inflammatory myopathies. The deliverable reflects regulatory writing focused on translating complex gene therapy procedures, risks, and study requirements into clear, patient centered language aligned with protocol requirements.

Clinical Article Summary: Distinguishing Postpartum Depression From Major Depressive Disorder

Developed a clinical article summary comparing postpartum depression and major depressive disorder across prevalence, risk factors, diagnosis, pathophysiology, symptoms, treatment, and barriers to care. The piece highlights distinctions relevant to clinical recognition and management, including peripartum specific presentation, mother infant considerations, and emerging treatment approaches targeting GABA A receptors.

Clinical Case Walkthrough Guide: Monitoring Methotrexate Clearance Using MTXPK.org

Developed a clinical case walkthrough illustrating the use of MTXPK.org to monitor methotrexate clearance and evaluate toxicity risk in a patient with primary central nervous system lymphoma receiving high dose methotrexate therapy. The guide presents patient characteristics, treatment context, predicted pharmacokinetic curves, and clinical insights related to delayed methotrexate clearance and management considerations.

Caregiver Education Resource: Supporting a Loved One With Major Depressive Disorder

Educational handout developed for healthcare professionals to share with patients and caregivers, providing guidance on recognizing symptoms of major depressive disorder and offering practical strategies for supporting a loved one during treatment. The resource also summarizes caregiver support approaches, crisis planning considerations, and additional mental health resources relevant to individuals affected by depression.

Provider Education Guide: Psychopharmacology Considerations for Clinical Practice

Provider focused educational resource summarizing key psychopharmacology principles relevant to treatment decision making in psychiatric care. The guide reviews pharmacokinetic concepts such as absorption, distribution, metabolism, and elimination, as well as pharmacodynamic mechanisms and potential medication interactions that influence the safe and effective use of psychotropic medications in clinical practice.
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